Cortisol Saliva Luminescence Immunoassay

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Details for:  Cortisol Saliva Luminescence Immunoassay
The IBL International Cortisol Saliva Luminescence Immunoassay is intended for the in-vitro-diagnostic quantitative determination of Cortisol in human saliva and for use as an aid in the diagnosis and treatment of adrenal disorders.

This device is not intended for point-of-care settings.

Cortisol (also known as hydrocortisone, compound F) is the main glucocorticoid in humans and is produced in the zona fasciculata of the adrenal cortex. 90 % of the circulating cortisol are bound to corticoid binding globulin (CBG, Transcortin), ca. 7 % are bound to albumin and only 1–3 % are unbound. Only the latter part represents the active form of cortisol. The free cortisol is released in saliva and is excreted via the kidneys as a small part among the metabolites of cortisol. The level of free cortisol in blood regulates mainly its secretion in the adrenal cortex in a negative feedback mechanism via CRH (corticotropin releasing hormone) in the hypothalamic region and the ACTH in the pituitary gland, but it is also affected by different situations above all by stress.

In humans there is a physiological fluctuation of cortisol achieving the highest level in the morning and the lowest during midnight. This fluctuation of cortisol plasma level is reflected in saliva normally with a peak in the first 90 minutes after wake up. The cortisol measurement is indicated in adrenal disorders. Due to the diurnal fluctuations of cortisol a salivary sample collection is an easy method without the stress of repeated venipunctures.

The Luminescence IA is also available in bulk format (10x96 tests), with the catalogue number RE62119. Please contact us if you should require a quotation.
This product replaces the former Cortisol Luminescence Immunoassay referenced RE62011/RE62019.
For concrete data please consult the Instruction for Use in the download box on the right side.

Catalog No. RE62111

Cortisol Saliva Luminescence Immunoassay
List Price $181
Kit size 12 x 8
Method Luminescence Immunoassay
Incubation time 1 x 3 h; 1 x 10 min
Standard range 0.015 - 3.20 µg/dL
Specimen / Volumes 20µL Saliva
Substrate / isotope Luminol
Regulatory Status: IVD, EU: CE

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