Epstein Barr Virus (EBV) EBNA-1 IgG ELISA
Infectious mononucleosis is an acute lymphoproliferative disease common in children and young adults and caused by the Epstein-Barr virus. The EBV is one of the herpes viruses 4 (gamma).
Characteristic clinical features include:
1. Fever, sore throat, and lymhadenopathy,
2. an associated absolute lymphocytosis (> 50% of which at least 10% are atypical lymphocytes in the peripheral blood),
3. development of transient heterophil and persistent antibody responses against EBV and
4. abnormal liver function.
4% of infected young adults show an icteric manifestation and 50% have splenomegaly. In addition, EBV is implicated in Burkitt lymphoma, nasopharyngeal carcinoma and Hodgkin´s disease.
An infectious mononucleosis similar syndrome can be caused by cytomegalovirus, toxoplasmosis and other viral infections. Therefore Differential diagnosis is of major importance. Serological tests like EIA are very useful for the detection of anti-EBV IgG and IgM antibodies especially when heterophil antibodies are absent. Related to fresh infections, IgM antibodies against VCA and EA are determined by immunofluorescence or ELISA. Later VCA IgG and then EBNA-1 IgG antibodies appear. The simultaneous activation of VCA IgM and EBNA-1 IgG indicates a reactivation of a latent EBV infection.
The IBL EBNA-1 IgG ELISA is helpful to monitor a past infection and may be utilized to assess blood samples prior to transfusions or transplantations.
For concrete data please consult the Instruction for Use in the download box on the right side.