Angiopoetin-like 4 (ANGPTL4) is a member of the angiopoietin/ANGPTL family. Human ANGPTL4 consists of 406 amino acids. Its protein structure is common to the angiopoietins, with a signal peptide regulating secretion, an N-terminal coiled-coil domain (CCD), a linker, and a C-terminal fibrinogen-like domain (FLD). Full-length ANGPTL4 is secreted by liver and adipose tissues and is cleaved to generate circulating CCD and FLD fragments. ANGPTL4 plays important roles in lipid and glucose metabolism. It inhibits lipoprotein lipase (LPL) activity by breaking the dimer molecule, and elevates plasma TG level. In the meantime, it has also been implicated in breast cancer metastasis to the lung via the regulation of vascular integrity. Both antibodies used in this ELISA kit recognize the N-terminal portion of human ANGPTL4 respectively.