17ß-Estradiol Saliva Luminescence Immunoassay

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Details for:  17ß-Estradiol Saliva Luminescence Immunoassay
Luminescence immunoassay for the in vitro diagnostic quantitative measurement of 17beta-Estradiol in human saliva. Results obtained by this device may be used in the diagnosis and treatment of various hormonal sexual disorders. This test is not intended for assessing placental function in complicated pregnancy.

17ß-Estradiol [1, 3, 5 (10) -estratriene-3, 17b-diol; E2] is a C18 steroid hormone and the most important natural estrogen. It is present in females and males. In the former, the estrogens stimulate the growth of sex organs and the development of secondary sexual characteristics, and they also affect the gonadotropin secretion.
In the males, the role of 17b-Estradiol is less well defined although it seems to be involved in the regulation of gonadotropin secretion. In non-pregnant women 17b-Estradiol is almost exclusively produced by ovary. Especially after having changed into the menopause, estrogenes are produced by the liver, the brain, the muscles and by the adipose tissue, too.
Moreover, the measurement of 17b-Estradiol is helpful to determine a lack of estrogenes, which may be expressed as delayed puberty, primary and secondary amenorrhoea, and occurs in the menopause. Other hormone assays are required for proper interpretation and differential diagnosis. The concentration of gonadotropin should be measured to find the origin of the lack of estrogenes (synthesis or regulation). The determination of 17b-Estradiol is useful for the diagnosis of pubertas praecox of girls. Concerning men, the level of 17b-Estradiol may be used for the differential diagnosis of gynecomastia. Being principally bound to sex hormone binding globuline (SHBG) and to serum albumin, only 1 - 3 % of estradiol circulating in plasma is present in its free form. Only this portion represents the active part in the endocrine regulation. The free hormone is released in equal amounts in saliva.

Because the fluctuations of the 17ß-Estradiol levels depends also on individual situations, it is very convenient to get a hormone profile by repeatedly collecting saliva samples.
For concrete data please consult the Instruction for Use in the download box on the right side.

Catalog No. RE62141

17ß-Estradiol Saliva Luminescence Immunoassay
List Price $243
Kit size 12 x 8
Method Luminescence Immunoassay
Incubation time 1 x 4 h; 1 x 10 min
Standard range 0.9 - 64 pg/mL
Specimen / Volumes 50 µL Saliva
Substrate / isotope Acridinium based
Regulatory Status: IVD


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