Cathepsin-L ELISA

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Details for:  Cathepsin-L ELISA
Cathepsin L is closely related to the recently described cathepsin V (L2) and the sequence indentity of almost 80% between them requires antibodies for the detection of cathepsin L which do not crossreact with cathepsin V. This requirement can only be met by epitope specific monoclonal antibodies as are used in BE59211.
Cathepsin L is a lysosomal cysteine proteinase consisting of a heavy chain of about 25 kDa and a light chain of about 5 kDa derived proteolytically from the same precursor. Cathepsin L has been shown to be produced by many different cell types. Since cathepsin L is capable of degrading protein constituents of the extracellular matrix it is assumed to play a crucial role in tumor progression and metastasis and a number of other disorders where the destruction of the extracellular matrix is the major cause of disease (e.g. rheumatoid arthritis, neurodegeneration). Synonyms: Major excreted protein, MEP, Cathepsin L precursor
For concrete data please consult the Instruction for Use in the download box on the right side.

Catalog No. BE59211

Cathepsin-L ELISA
List Price $501
Kit size 12 x 8
Method ELISA
Incubation time 1 x 2h, 1 x 1h, 1 x 10min.
Standard range 3.12 - 50 ng/mL
Specimen / Volumes 50 µL serum, plasma, cell culture supernatant et al.
Substrate / isotope TMB 450 nm
Regulatory Status: For research use only