Anti-HMGB1,2 Mouse IgG1 Monoclonal Antibody

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Details for:  Anti-HMGB1,2 Mouse IgG1 Monoclonal Antibody
transcription and DNA recombination. HMG proteins contain a highly acidic C-terminal domain as well as two evolutionarily conserved high mobility group (HMG) box motifs as their N-terminus. HMG boxes are found in numerous DNA binding proteins and transcription factors and allow HMG proteins to bind and to bend DNA. Especially, HMGB1 is known as amphoterin, it mediates neurite outgrowth, and it binds receptors for advanced glycation end products (RAGE). Recently, HMGB1 was unexpectedly identified as a cytokine through studies of endotoxemia and sepsis.

The antibody recognizes human, rabbit, bovine, pig, rat, and mouse HMGB1 and HMGB2. The specificity of the antibody was confirmed by western blot analysis. A hybridoma of the antibody was established by fusion of mouse myeloma cell P3U1 and BALB/c mouse spleen cell immunized with recombinant human HMGB1. This antibody was purified from the cell culture medium using Protein A Sepharose.
For concrete data please consult the Instruction for Use in the download box on the right side.

Catalog No. ST326052240

Anti-HMGB1,2 Mouse IgG1 Monoclonal Antibody
List Price $1,057
Quantity / Tests 50 µg
Species / Antigen human, rabbit, bovine, pig, rat, mouse
Host mouse
Subclass / Clone IgG1
Type monoclonal
Purification Protein A Sepharose
Label N/A
Regulatory Status: For research use only

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