Anti-HMGB1 Rabbit IgG Polyclonal Antibody

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Details for:  Anti-HMGB1 Rabbit IgG Polyclonal Antibody
HMGB1 and HMGB2 are chromatin-associated nuclear proteins that play an important role in transcription and DNA recombination. HMG proteins contain a highly acidic C-terminal domain as well as two evolutionarily conserved high mobility group (HMG) box motifs as their N-terminus. HMG boxes are found in numerous DNA binding proteins and transcription factors and allow HMG proteins to bind and to bend DNA. Especially, HMGB1 is known as amphoterin, it mediates neurite outgrowth, and it binds receptors for advanced glycation end products (RAGE). Recently, HMGB1 was unexpectedly identified as a cytokine through studies of endotoxemia and sepsis.

The antibody recognizes human, rabbit, bovine, pig, rat, and mouse HMGB1 but not HMGB2. The specificity of the antibody was confirmed by western blot analysis. A synthetic peptide corresponding to amino acids (KPDAAKKGVVKAEK) of human HMGB1 was used as an immunogen. The antibody was purified by affinity chromatography.
For concrete data please consult the Instruction for Use in the download box on the right side.

Catalog No. ST326059652

Anti-HMGB1 Rabbit IgG Polyclonal Antibody
List Price $1,068
Quantity / Tests 50 µg
Species / Antigen human, rabbit, bovine, mouse, rat, pig
Host Rabbit
Subclass / Clone No
Type polyclonal
Purification Affinity Purified
Label No
Regulatory Status: For research use only