APO-1 (Fas, CD95) ELISA

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Details for:  APO-1 (Fas, CD95) ELISA
Formerly sold as BE51901.

Programmed cell death or apoptosis is the most common form of eukaryotic cell death and is found during tumor regression and embryonic development. In the process of selection and eliminiation of autoreactive B and T cells apoptosis is an important process and therefore a prerequisite for the homeostasis of the immune system. Apoptosis is characterized by changes in cellular morphology (e.g. nuclear condensation, membrane bledding) and biochemically by rapid induction on DNA fragmentation. APO-1/Fas (CD95), a member of the TNF/NGF receptor superfamily, is a glycosylated 48kD surface protein containing a single transmembrane region. APO-1 is expressed on a variety of human B and T cell lines, on many different tumor cells and on various normal human tissues. Triggering of APO-1 by its ligand or by certain anti-APO-1 monoclonal antibodies results in rapid induction of programmed cell death, apoptosis, in susceptible cells. The tissue distribution of APO-1 and of the APO-1 ligand suggests that the APO-1 receptor/ligand system plays an important role in various aspects of mammalian development and especially in the homeostasis of the immune system. sAPO-1 may prevent cells from undergoing APO-1 ligand induced apoptosis.

Synonyms: Fas receptor, APO-1 cell surface antigen, CD95 antigen
For concrete data please consult the Instruction for Use in the download box on the right side.

Catalog No. 30150490

APO-1 (Fas, CD95) ELISA
List Price $501
Kit size 12 x 8
Method ELISA
Incubation time 2x1h, 1x10min
Standard range 15.6 - 1000 pg/mL
Specimen / Volumes 10 µL serum, cell culture supernatant
Substrate / isotope TMB 450 nm
Regulatory Status: For research use only