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Details for:  CD28 ELISA
CD28 is a 44 kDa, disulphide- bonded, homodimeric glycoprotein, which is constitutively expressed on the surface of the majority of T-cells. CD28 is structurally very closely related to another molecule expressed in activated T-cells, CTLA-4. Ligation of CD28 by its counter receptor, B7, expressed on the surface of antigen presenting cells, has been shown to induce signals that, in synergy with those derived from engagement of the T-cell receptor by an antigen bound to a major histocompatibilty complex, enhance proliferation and cytokine production. Manipulation of this interaction can have dramatic effects on the outcome of T-cell activation. Considerable research has been done on the CD28/B7 costimulatory pathway. Blocking thereof results in immunosuppression with implications for the treatment of autoimmune diseases, allergy, organ transplantation and graft versus host disease. Activating the CD28/B7 pathway could be useful for including the immune system to recognize and eliminate tumors that evade the immune system.

Synonyms: T-cell-specific surface glycoprotein, TP 44
For concrete data please consult the Instruction for Use in the download box on the right side.

Catalog No. BE59181

List Price $501
Kit size 12 x 8
Method ELISA
Incubation time 1 x 2h, 1 x 1h, 1 x 10min.
Standard range 0.78 - 50 ng/mL
Specimen / Volumes 50 µL serum, cell culture supernatant
Substrate / isotope TMB 450 nm
Regulatory Status: For research use only