11-Desoxycortisol RIA (CT)

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Details for:  11-Desoxycortisol RIA (CT)
Radioimmunoassay for the in vitro quantitative measurement of 11-Desoxycortisol in human serum.

 11-Desoxycortisol (Compound S) is an intermediate steroid in the glucocorticoids biosynthesis. Precusor of the cortisol, it comes from 17-hyroxyprogesterone after action of the 11 beta hydroxylase. This parameter is interesting for the diagnosis and follow up of treatment in case of surrenal enzymatic deficiency in 11 beta hydroxylase which is responsible for congenital surrenal hyperplasia in children and hyperandrogenics in adult women.

Under hypothalamic-pituitary control via the Adrenocorticotropic hormone (ACTH), the secretion of 11-Desoxycortisol follows a nycthemeral variation: it reaches a maximum in the morning (around 8 a.m.) and a minimal during the night (between 0 to 4 a.m.).

The measure of the 11-Desoxycortisol can be performed in serum using immunological competition methods (RIA).

The metopyrone inhibits the 11 beta hydroxylase and the conversion of the 11-Desoxycortisol in cortisol.

The metopyrone test is an indicator of the ACTH reserve.

For concrete data please consult the Instruction for Use in the download box on the right side.

Catalog No. MG11111

11-Desoxycortisol RIA (CT)
List Price $375
Kit size 96
Method RIA CT
Incubation time 2,5 h 37°C
Standard range 0,3 - 65 ng/mL
Specimen / Volumes 25 µL Serum
Substrate / isotope 125I < 105 kBq
Regulatory Status: For research use only