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Details for:  t-PA ELISA
Tissue-type plasminogen activator (t-PA) is a serine protease which occurs in blood plasma, serum, other body fluids, tissues and conditioned media of certain cultured cells. It can convert the inactive proenzyme plasminogen to the active protease plasmin. Plasmin can degrade fibrin, the matrix of a blood clot in a process known as fibrinolysis, leading to dissolution of the clot. Furthermore plasminogen activation is implicated in metastatic spread of malignant cells and in tissue remodelling.

Elevated levels of t-PA in serum were shown to occur in relation to retinopathy in type 1 diabetes mellitus. The major field of clinical interest is the field of diseases of the heart. t-PA plasma levels have been shown to be altered with the presence of transplant coronary artery disease in cardiac transplant recipients. A correlation between low serum levels of t-PA activity and thrombotic tendency has been described.

Synonyms: Tissue-type plasminogen activator
For concrete data please consult the Instruction for Use in the download box on the right side.

Catalog No. BE59411

List Price $501
Kit size 12 x 8
Method ELISA
Incubation time 1 x 2h, 1 x 10min
Standard range 15.6 - 1000 pg/mL
Specimen / Volumes 10 µL serum, cell culture supernatant
Substrate / isotope TMB 450 nm
Regulatory Status: For research use only