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Details for:  IGF-I ELISA
Measurement of human IGF-I in human serum and plasma samples. For Research Use only. Not for use in diagnostic procedures.

Insulin-like growth factors (IGF) I and II play a pivotal role in regulating the proliferation, differentiation and specific functions of many cell types. IGF-I is identical with Somatomedin C (Sm-C) and has a molecular weight of 7649 daltons. Its major regulators are growth hormone (GH) and nutrition, although its production in specific tissues is affected by a multitude of tropic hormones and other peptide growth factors. In contrast to many other peptide hormones, IGFs are avidly bound to specific binding proteins (IGFBP). The seven classes of IGFBPs which are known at present either bind IGF-I and IGF-II with similar affinities or show a preference for IGF-II.
A major problem of IGF-I measurement results from the interference of IGFBPs in the assay. Direct determinations in untreated serum samples give false values because of the extremely slow dissociation of the IGF-I/IGFBP-3 complexes during the assay incubation. Depending on the ratio IGF-I to IGFBP in the sample interference comes up. To avoid these difficulties, an uncomplicated assay was developed, in which special sample preparation is not required before measurement
For concrete data please consult the Instruction for Use in the download box on the right side.

Catalog No. MD58011

List Price $569
Kit size 12 x 8
Method ELISA
Incubation time 1 x 1h (RTS), 1 x 30 min (RTS), 1 x 15 min
Standard range 42 - 1050 ng/mL (1:21 dil.) or 20 - 500 ng/mL (1:10 dil.)
Specimen / Volumes 10 µL Serum or Plasma
Substrate / isotope TMB, 450 nm
Regulatory Status: For research use only


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