GLP-1 Active ELISA

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Details for:  GLP-1 Active ELISA
Incretins are a group of gastrointestinal hormones that cause an increase in the amount of insulin released from the beta cells of the islets of Langerhans after eating. They also inhibit glucagon release from the alpha cells of the islets of Langerhans. As a result, they slow the rate of absorption of nutrients into the blood stream by reducing gastric emptying and may directly reduce food intake. The two main candidate molecules that fulfill criteria for an incretin are glucagon-like peptide-1 (GLP-1) and Gastric inhibitory peptide (or glucose-dependent insulinotropic polypeptide or GIP). The human proglucagon gene was cloned in 1983, and the human proglucagon sequence was subsequently deduced. After that, it was found that the specific sequence of GLP-1 has insulinotropic effect: GLP-1 (7-36) amide. Now, GLP-1 (7-36) amide and GLP-1 (7-37) are known as active forms of GLP-1. They are rapidly inactivated to GLP-1 (9-36) amide and GLP-1 (9-37) by DPP-IV within a few moments in blood. Currently, Several DPP-IV inhibitors that can be taken orally as a tablet have already been developed as a treatment for diabetes. This ELISA kit can measure active forms of GLP-1 (GLP-1 (7-36) amide and GLP-1 (7-37)) specifically.
For concrete data please consult the Instruction for Use in the download box on the right side.

Catalog No. RE53121

GLP-1 Active ELISA
List Price $573
Kit size 12 x 8
Method ELISA
Incubation time 1 x 20-24 h, 1 x 20 min
Standard range 0.64 - 48 pmol/L
Specimen / Volumes 100 µL serum, EDTA-plasma
Substrate / isotope TMB 450 nm
Regulatory Status: For research use only