HMGB1 ELISA

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Details for:  HMGB1 ELISA

Multi-tasker of the innate immune system

Over the years, HMGB1 has increasingly attracted the attention of basic as well as clinical researchers and has become one of the most intriguing molecules within the complete arsenal of proteins of the innate immune system.

IBL International’s HMGB1 ELISA, which has been developed by Shino-Test Corporation, Japan, in cooperation with Prof. Dr. Ikuro Maruyama, Kagoshima University, is the worldwide renown assay to quantify HMGB1 in any experimental setting.

HMGB1
Figure: Redox control of HMGB1 activity (Tang D. et al. MolMed. 2012;18:1360-1362).

HMGB1 is a nuclear protein that can bind and bend DNA, but it can also be released to the extracellular environment where it exerts additional functions. The unraveling of the post-translational modifications has led to a better understanding of the mechanism of its translocation and its function within the immune system. It will now also allow more in-depth studies into the role of HMGB1 in numerous pathologies, including

  • Autoimmune diseases
  • Sepsis
  • Cancer
  • Diabetes
  • Cardial infarction
  • Stroke
  • ... any inflammatory process

HMGB1

Through its collaboration with HMGB1 experts from academia and commercial partners, IBL International is at the forefront of new developments. We at IBL offer the most complete range of products - including the highly sensitive ELISA for the quantitative measurement of HMGB1 - which have been widely used and are cited in many publications.

All conditions of HMGB1
Figure: HMGB1 biology by the current state of scientific knowledge

Excerpt from the Instructions for Use

The HMGB1 ELISA Kit was developed by Shino-Test Corporation, Japan, in cooperation with Prof. Dr. Ikuro Maruyama, Kagoshima University. The product is exclusively distributed worldwide by IBL International except in Japan, China (incl. Hong Kong) and Taiwan.

HMGB1 is an ubiquitous protein that can be found in all animals in the cytosol and the nucleus of the cells.
As a nucleus-binding protein it regulates amongst other things the gene transcription.
HMGB1 plays a major role in the pathogenesis of a lot of diseases.
So HMGB1 is important in the development and survival of tumours. It regulates by interaction with RAGE autophagy. It is late mediator in sepsis. It organizes cross-talk of NKs and DCs in viral infections. These findings represent only a small overview of HMGB1's role in medical research.

For concrete data please consult the Instruction for Use in the download box on the right side.

Catalog No. ST51011

HMGB1 ELISA
List Price $1,272
Kit size 12 x 8
Method ELISA
Incubation time 1 x 20-24h, 1 x 2h, 1 x 30min.
Standard range 2.5 - 80 ng/mL (HS: 0.313 - 10 ng/mL)
Specimen / Volumes 10 µl serum, plasma, cell culture supernatant et.al
Substrate / isotope TMB 450 nm
Regulatory Status: For research use only

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